IndraLab

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USP14 leads to the deubiquitination of TAB2. 4 / 4
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"USP14 Induces Deubiquitination of TAB 2 and Inhibits TLR4 Mediated Signaling."
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"These results suggest that USP14 induces the deubiquitination of TAB 2."
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"Since USP14 induced the deubiquitination of TAB 2, we then examined the functional regulation of TLR4 mediated signaling in Ctrl and USP14 KD THP-1 cells."
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"Taken together, our data demonstrate that <span class="match term0">USP14</span> can negatively regulate autophagy induction by inhibiting Beclin 1 ubiquitination, interrupting association between TRAF6 and Beclin 1, and affecting TLR4-induced activation of NF-kappaB through deubiquitination of TAB 2 protein"
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