IndraLab

Statements

CCND1 binds CDK4 and CDK6. 54 / 54
| 54
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"The activation of cyclin D1, which subsequently interacts with CDK4 or CDK6, leads to the inactivation of the restrictive G1 checkpoint, suppressing cell cycle arrest. xref In our study, DCZ0858 induced cell cycle arrest in the G0/G1 phase and inhibited cell transition into the S phase."
32257397
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"In contrast, overexpression of CDK4 or CCND1 alone resulted in no rescue, suggesting that binding of CCND1 to endogenous CDK4 or CDK6 is not sufficient to protect HSPCs from differentiation-inducing signals."
26150472
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"As a regulatory subunit of cyclin-dependent kinase (CDK), cyclin D1 forms complexes with CDK4 and CDK6, which were a central mediator in the transition from G1 to S phase."
27708248
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"The active form of STAT3 was found to promote the G/S phase transition of the cell cycle through the expression of cyclin D1, which can associate with cdk4 or cdk6 and control progression from G to S [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24388873
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"The binding of cyclin D1 with Cdk4 ( xref ) or Cdk6 ( xref ) was suppressed by Rh2 treatment."
19629651
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"CDK6 interacts with CDK4 and CCND1 to form a complex which is fundamental for Rb function and G1/S transition."
| PMC
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"Hyperphosphorylation of the retinoblastoma (Rb) gene product pRb is mediated in early G 1 by CDK4 and CDK6 interacting with cyclin D 1 ."
19874578
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"In the presence of mitogenic stimuli and abundant nutrients, cyclin D1 is synthesized; to perform its functions, cyclin D1 assembles with CDK4 or CDK6 to form a kinase complex; conversely, growth factor withdrawal or nutrient depletion compromises the formation of new cyclin D1-CDK4/6 complexes, leading to an immediate degradation of cyclin D1 in order to facilitate cell cycle exit [ xref ]."
32006569
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"In human cells, cyclin D1 interacts with CDK4 and CDK6 to form holoenzymes and then phosphorylates the tumor-suppressor protein Rb in G1 phase, which is important for cell cycle progression. xref The E2F transcription factor binds to Rb and is released when Rb is phosphorylated, inducing the expression levels of a series of genes, such as cyclin E, cyclin A, PCNA and MCM7, which are involved in entry into S phase of the cell division cycle. xref Our study showed that SH treatment downregulated the expression levels of the cell cycle-positive regulators, including CDK4, cyclin D1, cyclin E, phospho-Rb, PCNA and MCM7."
25077542
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"Once produced, cyclin D1 binds to either cyclin dependent kinase 4 (CDK4) or CDK6, dependent on cell type, and serves to activate the kinase moiety (Figure xref )."
16863592
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"In these clones, binding of p16 to cdk4 and cdk6 abrogated binding of cyclin D1, p27(KIP1), and p21(WAF1/CIP1)."
10207115
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"For instance, CCND1 binds to CDK4 or CDK6, which in turn phosphorylates Rb to promote G1/S transition [ xref ]."
28270228
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"To estimate this, we used a mutant form of cyclin D1 K112 (MT-cyclin D1) that could not bind to CDK4 or CDK6 ( xref )."
29437706
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"Under conditions where cyclin D1 was bound to cdk5, no significant binding of cyclin D1 to cdk4 or cdk6 was observed (data not shown)."
9150273
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"Previous studies suggest that the expression of cyclin D1 could be induced by growth factor stimulation, and cdk4 or cdk6 associated with cyclin D1 exhibits protein kinase activity [ xref - xref ]."
17261172
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"In this pathway, p16INK4a, an inhibitor of Rb pathway, binds to CDK4 and CDK6 competitively with cyclin D1 to prevent phosphorylation of tumor suppressor pRB gene."
18760195
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"Once cyclin D1 binds to cyclin-dependent kinase 4 (CDK4) or CDK6, phosphorylation of retinoblastoma protein (Rb) is triggered at the early stage of G1 phase, causing the release of E2F factors, which serve as transcription factors of the genes pushing the cell cycle from G1 phase to S phase ( xref , xref )."
29434772
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"Cyclin D1 forms cyclin D1-CDK4 or cyclin D1-CDK6 complexes by binding to CDK4 or CDK6."
36072972
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"This action requires cyclin D1 binding to CDK4 and CDK6, which phosphorylate and inactivate RB1, leading to the release of E2F transcription factors and the subsequent progression of the cell into the S phase [ xref ]."
24490161
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"The p16 gene product binds to CDK4 and CDK6 inhibiting their interaction with cyclin D1."
15985168
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"CCND1 acts mainly during the G1 phase and forms a complex with CDK4 or CDK6 in the mid to late G1 phase."
33112552
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"CCND1 binding with cyclin dependent kinase 4 (CDK4) or CDK6 is necessary for the G1/S transition [ xref ]."
30380668
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"It is noteworthy that AKT can be activated independently from the PI3K signaling, by IR-induced DNA double-strand break [ xref ], and that PI3K/AKT/mTOR pathway is crucial for the functional interaction between CCND1 and CDK4 and CDK6 [ xref ]."
| PMC
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"For example, the expression of cyclin D1, which is associated with cdk4 or cdk6 and controls progression from the G1 to the S phase, is elevated in constitutively activated STAT3 expressing cells."
12131365
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"A theoretically ideal inhibitor of the G1/S phase transition, yet to be developed, would be a small molecule mimetic of p16 INK4a that would inhibit assembly of cdk4 and cdk6 with cyclin D1."
16102574
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"It has been well established that activated CDK6 forms a complex with CDK4 and cyclin D1 and initiates the phosphorylation of pRb releasing E2F transcription factors, thereby driving the expression of genes required for cellular commitment to enter S phase and ultimately mitotic cell division ( xref )."
34395263
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"Induced cyclin D1 interacts with CDK4 or CDK6 and activates its kinase activity, which is required for G1/S cell cycle progression [ xref ]."
26569225
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"In the present study, flow cytometric analysis revealed that resveratrol induced A549 cells to arrest in the G 0 /G 1 phase and it was associated with a decrease in the protein level of cyclin D1, CDK4 and CDK6."
25515619
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"CCND1 forms complex with its specific kinase, CDK4 or CDK6, in early G1 phase, and these complexes functions during the entire G1 to S phase transition xref – xref ."
25409181
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"1 revealed that RP11-624l4.1 may directly interact with CDK4, CDK6 and CyclinD1 ( Figure 201 S5-S7, with probability 0.65, 0.6 and 0.65 respectively using Random Forest classifier, 202 with probability 0.98, 0.94 and 0.89 respectively using SVM)."
33078086
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"The cyclin D1 associates with CDK4 and CDK6 regulates progression from G1 into S phase."
| PMC
sparser
"As one of the most important cell cycle machineries, CDK6 forms an active complex with CDK4 and cyclin D1 to phosphorylate downstream proteins such as the retinoblastoma tumor suppressor protein (RB) and E2F transcription factors, activation of which finally promotes cell cycle progression through G1 to S phase ( xref , xref )."
34395263
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"P16 can compete with cyclin D1 binding to CDK6 or CDK4 and thus specifically inhibit CDK4 or CDK6 activity, eventually leading to cell cycle arrest at G1 phase ( xref , xref )."
28358412
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"c-Myc can induce cyclin D1 which interacts with CDK4 and CDK6 to promote cell cycle progression xref ."
20022709
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"The interaction of cyclin D1 with CDK4 and CDK6, leads to phosphorylation and thereby inactivation of the Rb-protein and its G1-maintaining function, which culminates in the expression of proliferation-associated target genes [ xref , xref ]."
25925673
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"Our previous study has shown that overexpression of ADNP in BC stimulated the Akt-MDM2-p53 pathway and enhanced binding of cyclin D1 to CDK4 or CDK6, accelerating the cell cycle transition from G1 phase to S phase xref ."
34335928
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"The cyclin D1 protein directly associates with CDK4 and CDK6 and stimulates catalytic activity of the complex ( xref , xref )."
18632615
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"Expression of cyclin D1, which associates with cdk4 or cdk6 to control progression from the G1 to S phases, has been found elevated in cells transfected with a constitutively active mutant of STAT3 or[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15727810
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"Ink4 proteins complex with CDK4 and prevent the binding of CDK4 or CDK6 to cyclin D1, leading to cell cycle arrest [ xref ]."
18777097
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"Cyclin D1 and p21 then drive the formation of active cyclin-D1–CDK4 (cyclin-dependent kinase-4) and cyclin-D1–CDK6 complexes, which promote cell-cycle progression by phosphorylating retinoblastoma (RB) proteins xref ."
19652721
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"Among them, both CDK4 and CDK6 can bind to cyclin D1 and play an important role in the G 1 /S phase ( xref )."
33692864
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"ADNP stimulates the AKT-MDM2-p53 pathway and enhances binding of cyclin D1 to CDK4 or CDK6, accelerating the cell cycle transition from G1 phase to S phase."
33240802
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"It has been established that cyclin D1 forms a complex with CDK4 or CDK6 and is absolutely required for G1/S transition."
24130852
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"Once expressed, cyclin D1 binds to CDK4 (cyclin-dependent kinase 4) or CDK6 to form an active holoenzyme that phosphorylates the retinoblastoma 1 (Rb1) protein."
24342356
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"CCND1 interacts with CDK4 and CDK6 and the activation of this complex phosphorylates RB and other transcription factors which promote cell cycle progression [ xref ]."
30770954
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"Since the G1 transition is promoted by cyclin D1 that forms a complex with CDK4 or CDK6 [ xref , xref ] and blocked by p21, a Cip/Kip family protein that inhibits the activity of CDKs [ xref ], we measured them by western blot analysis."
27721894
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"While p15INK4B and its binding to both cdk4 and cdk6 increased with increasing passage, some cyclin D1-bound cdk4 and cdk6 persisted in senescent cells, whose inhibition could not be attributed to p15INK4B. The inhibition of cyclin E-cdk2 in senescent HMECs was accompanied by increased inhibitory phosphorylation of cdk2, in association with a progressive loss of Cdc25A. Recombinant Cdc25A strongly reactivated cyclin E-cdk2 from senescent HMECs suggesting that reduction of Cdc25A contributes to cyclin E-cdk2 inhibition and G1 arrest at senescence."
11103932
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"Both CDK4 and CDK6 are closely associated with CCND1 in regulating cellular growth, and it is possible that CDK6 remained expressed in order to compensate the function of CDK4 in an attempt to rescue cell cycle arrest."
30949979
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"Association of cyclin D1 with CDK4 and CDK6 drives progression through G1 stage, cyclin E and cyclin A bind CDK2 to regulate centrosome duplication and also to target helicases and polymerases during G1/S and S-phase, and cyclin A/cyclin B/CDK1 complexes regulate the G2/M checkpoint ( xref )."
29097609
sparser
"Silibinin has been reported to inhibit cell growth and induce G1 arrest in cell cycle progression of human prostate carcinoma, which was associated with decreased levels of cyclin D1, CDK4, and CDK6 and induction of Cip1/p21 and Kip1/p27, followed by increased binding with CDK2 [ xref , xref ]."
28030611
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"The binding of cyclin D1 to CDK4 and CDK6 is a rate-limiting step during cell cycle progression [34] ."
24767859
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"Activated cyclin D1 forms complexes with Cdk4 and Cdk6, and these complexes act in the early G1 phase of the cell cycle; conversely, cyclin E forms complexes with Cdk2 and act in the late G1 phase and S phase of the cell cycle ( xref )."
29767250
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"CCND1 binds to cyclin-dependent kinase 4 (CDK4) as well as CDK6 and promotes G1 to S phase progression by inhibiting RB xref ."
29849070
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"Then it forms cyclin D1-CDK4 or cyclin D1-CDK6 complexes, activates CDK, and phosphorylates the key substrate retinoblastoma gene (Rb), which enables the cells to enter S phase through the restriction point."
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