IndraLab

Statements

USP7 inhibits FOXO1. 3 / 3
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"However, in contrast to the stimulating activity of MATH-33, USP7 negatively regulates FOXO1 and FOXO4 [42,43] ."
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"USP7 reverses this monoubiquitylation, and thereby restricts FOXO1 and FOXO4-dependent transcriptional responses."
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"For example, the deubiquitylase MATH-33 recently has been reported to stabilize and activate DAF-16 by antagonizing polyubiquitylation, while its mammalian counterpart USP7 and HAUSP inhibits FOXO1 and FOXO4 by decreasing their nuclear localization and transcriptional activity, respectively, by removing monoubiquitin moieties [XREF_BIBR - XREF_BIBR]."
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