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USP2 inhibits signal transduction. 2 / 2

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"Consistently, we found that PPAR-γ knockdown increased and Usp2 overexpression decreased the expression of FoxO signaling pathway-related genes, including cyclin G2 (Ccng2), cyclin-dependent kinase inhibitor 1B (Cdkn1b), retinoblastoma-like protein 2 (Rbl2), and Bcl-2 interacting protein 3 (Bnip3) (Fig. 6B)."

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"Conversely, USP2 inhibits glioblastoma development by suppressing the TGF-B signaling pathway through the deubiquitination of SMAD7 [19]."

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USP2 inhibits signal transduction. 2 / 2

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