IndraLab

Statements

CALR binds CD47. 12 / 12
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"We have shown that CALR interacts with CD47 ( xref ), an integrin-associated transmembrane protein, which stimulates the escape of cancer cells from immune surveillance ( xref )."
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"Involvement of the CALR-CD47 regulatory axis."
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"Abnormalities in the PI3K/Akt signaling pathway deregulation of C/EBP-α and its partner PPAR-γ , and the interaction between calreticulin (CRT) and CD47 are also promising therapeutic targets."
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"3) The results presented for the Calreticulin-CD47 signaling axis dissected in Figure 5 appear incomplete."
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"This study presented the generation of MSC-derived iTSCs by activating PKA signaling and evaluated the role of CALR-CD47 and PCOLCE-APP regulatory axes in suppressing the progression of OS ( xref )."
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"In the CALR-CD47 regulatory axis, the results in this study revealed that extracellular CALR inhibited CD47’s tumorigenic actions."
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"Abnormalities in the PI3K and Akt signaling pathway deregulation of C/EBP-alpha and its partner PPAR-gamma, and the interaction between calreticulin (CRT) and CD47 are also promising therapeutic targets."
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"As suggested, we evaluated the CALR-CD47 interactions using the same approach to evaluate the PCOLCE-APP interactions in Figure 7E. Silencing CD47 also downregulated MTT-based viability, whereas it significantly suppressed Calr-induced tumor inhibition in U2OS OS cells, TT2 OS cells, MDA-MB-231 breast cancer cells, and PANC1 pancreatic cells."
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"In DMM, calreticulin expression was not statistically associated with CD47 expression levels ( xref )."
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"– The results presented for the Calreticulin-CD47 signaling axis dissected in Figure 5 appear incomplete."
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"The proteins were then transferred to a polyvinylidene fluoride membrane, blocked for 1 h with a 5% skimmed milk solution, and incubated overnight at 4 °C with the following primary antibodies: anti‐PD‐L1 (A1645, ABclonal), anti‐B7‐H3 (A17216, ABclonal), anti‐calreticulin (A11563, ABclonal), anti‐CD47 (A21904, ABclonal), anti‐VP1 (M47, Mediagnost), and anti‐CD39 (A3778, ABclonal)."
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"They focused on CALRETICULIN-CD47, PCOLCE-APP, and CALRETICULIN-APP interactions to highlight their approach as a proof of concept that perhaps identifying the proteins secreted by cancer cells can offer novel approaches to target osteosarcomas."
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