IndraLab

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OTUD5 deubiquitinates YAP1. 5 / 5
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"Furthermore, we report for the first time that OTUD5 deubiquitinates and stabilizes YAP in macrophage."
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"In breast cancer, OTUD5 deubiquitinates and stabilizes YAP in macrophages, and YAP promotes M2 macrophage polarization, which is beneficial for enhancing the metastatic ability of breast cancer cells [12]."
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"In addition, OTUD5 can also mediate YAP deubiquitination in macrophages and subsequently promote M2 phenotype polarization, which facilitates the progression of triple-negative breast cancer [10]."
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"We next examined the possibility that OTUD5 might deubiquitinate YAP through its deubiquitinating enzyme activity."
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"We proved that dapagliflozin decreased the expression level of OTU deubiquitinase 5 (OTUD5), which further increased the ubiquitination and degradation of YAP1."
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