IndraLab

Statements

CDIPT inhibits KCNH2. 2 / 2
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"Although PIs block in vitro hERG current, they are not independently associated with QTc interval prolongation."
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"Fridericia 's corrected QT interval versus nelfinavir (top) and M8 (bottom) plasma concentrations.DISCUSSION Anson et al (2005) showed that various PIs including lopinavir, ritonavir, saquinavir and nelfinavir, caused a dose dependent blockage of HERG channel in cellbased in vitro assays.7 However, only a few clinical studies have examined the effect of protease inhibitors on QT interval prolongation."
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