IndraLab

Statements

MiR-192-5p decreases the amount of SCN5A. 4 / 4
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"In our previous study, we revealed that miR-192-5p bound to the 3′-UTR of human SCN5A to negatively regulate the expression of Nav1.5 and reduce I density."
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"With Western blot assays and electrophysiological studies, we demonstrated that miR-192-5p significantly reduced expression of SCN5A and Nav1.5 as well as peak sodium current density INa generated by Nav1.5."
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"Mechanistically, miR-192-5p can bind to the 3 '-UTR region of SCN5A, and repress the expression of SCN5A and Nav1.5, thereby aggravating arrhythmia."
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"For example, inhibitors of miR-192-5p may be used to increase SCN5A expression or enhance density of I Na, and treat patients with down-regulation of SCN5A or reduced I Na density as in AF, heart failure, myocardial ischemia, BrS and other arrhythmias."
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