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Fluconazole decreases the amount of KCNH2. 3 / 3
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"Our findings have demonstrated that the combination of fluconazole and terbinafine could also significantly reduce the expression of ERG1, 3, and 11 in the cell membrane of Candida in all concentrations tested ranging from 1.73- to 6.99-fold."
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"Mutations in drug-binding sites (Y652 and F656) inside the channel cavity attenuate hERG current blockade, but do not affect the reduction of hERG surface expression induced by fluoxetine, roxithromyc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results show that fluconazole reduces the expression of mature hERG channels on the cell surface, possibly by disrupting channel trafficking.Fluconazole is a systemic antifungal medication that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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