IndraLab

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N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits RELA. 13 / 14
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"Elevated cAMP or NLS-Actin R62D reduced the half-life of RelA/p65, which was reversed by the proteasome inhibitor MG132."
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eidos
"However , MG-132 as a proteasome inhibitor was found to markedly inhibit the expression of p65 ( Figures S4 ( A ) and ( E ) ) , which was in line with other cell types [ 38 , 39 ] ."
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"These results suggest that MG132 blocks the activation of NF-κB (p65) signaling pathways induced by RGS12."
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"Elevated cAMP or NLS-Actin R62D reduced the half-life of RelA/p65, which was reversed by the proteasome inhibitor MG132."
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"We observed that DOX induces upregulation of the p65 gene, and that MG132, alone or in combination with DOX, downregulated p65."
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"In addition, in our study, MG-132, an NF-kappaB inhibitor, abrogated the upregulation of p65 and APE-1 mRNA and protein levels induced by MCP-1."
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"Overexpression of PPP1R13L also depleted the cells of the NF-kappaB subunit, RelA, which again could be reversed by MG132."
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"Western blot results showed that MG132 also degraded p65 (XREF_FIG) and Sp3 (DeltaSp3) (XREF_FIG) proteins."
| PMC
sparser
"In contrast, MG-132 inhibits CDG-induced RelA, but not IRF3, nuclear translocation in BMDMs and BMDCs ( xref )."
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"The immunoblotting results showed that the degradation of p65 induced by SOCS1 was inhibited MG132 only ( Fig. 5 G), which demonstrated SOCS1 promoted the degradation of p65 through ubiquitination."
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"The expression of RelA was decreased after treated with MG-132 in DU145 cells transfected either with control-siRNA or RelB-siRNA in a time dependent manner."
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"Based on our results, NF-kappaB p65 expression was significantly blocked after treated with MG-132 and co-treatment with isoflurane and MG-132."
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"Furthermore, expression of Bcl-2 in Bcl-2–deficient HEK293T cells caused degradation of nuclear p65, which was restored by MG132 treatment."
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