IndraLab

Statements

USP10 inhibits Neoplasms. 6 / 8
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"Additionally , USP10 blocks tumor formation via p53 and SIRT6-mediated degradation of c-Myc , thereby stopping cell cycle progression and cancer cell growth [ 53 ] ."
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"The overexpression of USP10 can inhibit the formation of stress granules (SGs), thus restraining the development of a tumor [19,24]."
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"For example , in hepatocellular carcinoma , Zhu et al. reported that USP10 promotes proliferation [ 40 ] , whereas Lu et al. found that USP10 suppresses tumor progression by inhibiting mTOR activation [ 41 ] ."
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"Furthermore, USP10 can also interact with and deubiquitinate PTEN, USP10 inhibition stimulates tumor growth and invasion, but this effect can be abolished by reinserting PTEN (Sun et al., 2018)."
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"USP10, upon ATM-dependent phosphorylation at threonine 42 and serine 337 residues, is stabilized and translocated to the nucleus to activate p53 through deubiquitinating activity, inducing tumor cell suppression [53]."
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"CAPRIN-1 enhances proliferation [ 71,72,73 ] , whereas USP10 inhibits tumor progression and invasion [ 74,75 ] ."
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