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USP10 inhibits Neoplasms. 11 / 13
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"For example , in hepatocellular carcinoma , Zhu et al. reported that USP10 promotes proliferation [ 40 ] , whereas Lu et al. found that USP10 suppresses tumor progression by inhibiting mTOR activation [ 41 ] ."
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"A particularly important observation was that knockdown of USP10 in wild-type p53 cell lines promoted proliferation and metastasis, suggesting that USP10 could inhibited tumor development under the background of wild-type p53."
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"And we also logically argue that the USP10-mediated antitumor effect in CRC may largely depend on its inhibition on Wnt/β-catenin instead of other pathways, given the fact that all other tumor-suppres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For instance, USP10 is reduced in gastric, 37 lung, 38 liver, and colon 39 cancer tissues and inhibits tumor growth."
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"USP10 acts as the hub in this process, thus enabling LKB1/AMPK to suppress tumor growth via regulation of both metabolism and cell proliferation."
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"Additionally , USP10 blocks tumor formation via p53 and SIRT6-mediated degradation of c-Myc , thereby stopping cell cycle progression and cancer cell growth [ 53 ] ."
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"CAPRIN-1 enhances proliferation [ 71,72,73 ] , whereas USP10 inhibits tumor progression and invasion [ 74,75 ] ."
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"Furthermore, USP10 can also interact with and deubiquitinate PTEN, USP10 inhibition stimulates tumor growth and invasion, but this effect can be abolished by reinserting PTEN (Sun et al., 2018)."
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"The overexpression of USP10 can inhibit the formation of stress granules (SGs), thus restraining the development of a tumor [19,24]."
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"Immunohistochemical analysis showed that Spautin-1 attenuated the expression levels of USP10, RUNX1 and MES markers and enhanced PN markers in xenograft tumors of nude mice (Supplementary Fig. S6E)."
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"Hence, deubiquitination of PABPC1 by USP10 stimulates the progression of PDAC, while the PABPC1 mutant that cannot be ubiquitinated slowed tumor suppression mediated by USP10-KD."
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