IndraLab

Statements

USP22 inhibits ferroptosis. 17 / 17
| 17
reach
"Overexpression of USP22 reversed LPS-induced cellular inflammation, attenuated decidualization, and inhibited ferroptosis."
38896999
reach
"In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]."
36792890
reach
"A recent study uncovered that USP22 can repress the transcriptional activity of p53 to upregulate SLC7A11 expression, thereby suppressing ferroptosis in cardiomyocytes [28]."
35761309
reach
"USP22 inhibits Sorafenib‐induced ferroptosis through transcriptional suppression of TFRC mediated by deubiquitinating H2BK120ub."
40341781
reach
"Additionally, A549 and H1975 LUAD cells with USP22 silencing exhibited a higher expression of ACSL4 and lower levels of SLC7A11 and GPX4 than sh‐Ctrl controls; however, these changes could be markedly reversed by COL17A1 reexpression (Figure 6J,K), indicating that USP22 silencing induces cell ferroptosis via COL17A1 downregulation."
39143031
reach
"USP22 promotes gefitinib resistance and inhibits ferroptosis in non-small cell lung cancer by deubiquitination of MDM2."
39315600
reach
"Additionally, USP22 acts as a novel inducer of Sorafenib resistance and suppresses Sorafenib-triggered ferroptosis in hepatocellular carcinoma cells."
40341781
reach
"Our results showed that USP22 knockout enhanced ferroptosis induced by different drugs, as evidenced by decreased cell viability (Figure S5A) and elevated cellular lipid ROS levels (Figure S5B) compared to control cells."
40341781
reach
"Similarly, through the SIRT1/p53/SLC7A11 connection, USP22 overexpression may prevent ferroptosis-induced cardiomyocyte death and shield against MI/RI [40]."
39354361
reach
"Finally, in vivo study proved that miR-144-3p antagomir could restore the impaired function of pancreatic β-cells by suppressing ferroptosis to exert anti-hyperglycemic effect on T2DM mice.In short, the abnormal up-regulation of miR-144-3p clearly suppressed the expression of USP22 mRNA and inhibited its downstream effects on the ferroptosis pathway to cause the dysfunction of pancreatic β cells (Fig. 6), thereby promoting the progression of T2DM."
35761309
reach
"To prove that the upregulation of TFRC transcription mediates the promotion of ferroptosis caused by USP22 knockout, we knocked down TFRC expression through transfecting its specific small interfering RNAs (siRNAs) into USP22 knockout cells (Figure 7A), and subsequently measured cell viability, cell death, cellular lipid ROS, cellular GSH and Fe levels."
40341781
reach
"Taken together, these results suggested that inhibition of USP22 enhances ferroptosis sensitivity by downregulating SCD, thereby contributing to the reduction of melanoma metastasis (Figure 7J).3 DISCUSSION."
39135915
reach
"Taken together, our findings demonstrated that USP22 inhibits Sorafenib‐induced ferroptosis through the transcriptional inhibition of TFRC.2.8 USP22 depletion inhibits hepatocellular carcinoma growth and sensitises hepatocellular carcinoma to Sorafenib treatment in mice."
40341781
reach
"In addition, overexpression of USP22 can reduce ferroptosis, accompanied by an increase in GSH and a decrease in ROS production, lipid peroxidation and iron accumulation (Ma et al., 2020)."
35478955
reach
"Through the SIRT1/p53/SLC7A11 axis, USP22 may suppress ferroptosis in cardiomyocytes in vivo, thereby playing a crucial role in preventing myocardial ischemia/reperfusion injury [64]."
38105650
reach
"USP22/MDM2 promoted gefitinib resistance and inhibited ferroptosis in NSCLC, which might offer a novel strategy for overcoming gefitinib resistance in NSCLC."
39315600
reach
"Increases in USP22, SIRT1, or SLC7A11 attenuated ferroptosis and ameliorated cardiac function, which was accompanied by reduced ROS production, lipid peroxidation and iron accumulation."
36358568