IndraLab

Statements

OTUB2 activates lactate. 6 / 6
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"Fourth, although we determined that OTUB2 promoted glycolysis and increased the lactate content in VSMCs, we did not investigate whether OTUB2 regulates histone lactylation levels during VC progression."
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"Moreover , OTUB2 depletion reduces glucose consumption , lactate production , and cellular ATP production ."
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"Conversely, OTUB2 overexpression substantially enhanced glycolytic capability, glucose uptake and extracellular lactate production in XL-2 and H292 cells."
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"As expected, we verified that OTUB2 overexpression increased ECAR, glucose uptake, and lactate production, while knockdown of OTUB2 impaired the aerobic glycolytic phenotype in different NSCLC cell lines."
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"Moreover, OTUB2 depletion reduces glucose consumption, lactate production, and cellular ATP production."
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"Analyses using a Seahorse XF96 analyzer revealed that OTUB2 deficiency suppressed glycolytic flux and decreased the production of lactate."
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