IndraLab

Statements

Lumacaftor activates KCNH2. 2 / 2
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"Incubation with E-4031, but not lumacaftor, rescued defective hERG-T634S channel trafficking and I hERG density."
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"Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) of two LQT2 patients, we tested whether the commercial association Lumacaftor + Ivacaftor (LUM + IVA) could shorten the QTc in the same two patients."
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