IndraLab

Statements

USP7 activates REST. 7 / 18
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"In contrast, HAUSP overexpression up-regulates REST by overriding beta-TrCP-mediated ubiquitination."
21258371
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"In contrast, HAUSP (the herpesvirus associated ubiquitin specific protease, also known as USP7) had been shown to suppress REST degradation through a deubiquitination process [XREF_BIBR]."
29156689
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"Here, we demonstrated that deubiquitinase HAUSP (Herpesvirus Associated Ubiquitin Specific Protease, also known as Ubiquitin Specific Protease 7, USP7) XREF_BIBR, XREF_BIBR prevents REST degradation through deubiquitination and promotes NPC maintenance."
21258371
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"Functional disruption of HAUSP in NPCs reduces REST protein and induces neuronal differentiation."
22569092
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"HAUSP knockdown in NPCs decreases REST and induces differentiation."
21258371
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"Theoretically, HAUSP might indirectly modulate REST through transcriptional control but we confirmed that HAUSP knockdown did not alter REST mRNA expression on RT-PCR analysis (XREF_FIG)."
21258371
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"HAUSP knockdown in NPCs decreased REST and induced differentiation."
23483195