IndraLab

Statements

USP7 activates REST. 8 / 19
| 8
reach
"HAUSP knockdown in NPCs decreases REST and induces differentiation."
21258371
reach
"Here, we demonstrated that deubiquitinase HAUSP (Herpesvirus Associated Ubiquitin Specific Protease, also known as Ubiquitin Specific Protease 7, USP7) XREF_BIBR, XREF_BIBR prevents REST degradation through deubiquitination and promotes NPC maintenance."
21258371
reach
"In contrast, HAUSP (the herpesvirus associated ubiquitin specific protease, also known as USP7) had been shown to suppress REST degradation through a deubiquitination process [XREF_BIBR]."
29156689
reach
"In contrast, HAUSP overexpression up-regulates REST by overriding beta-TrCP-mediated ubiquitination."
21258371
reach
"Functional disruption of HAUSP in NPCs reduces REST protein and induces neuronal differentiation."
22569092
reach
"HAUSP knockdown in NPCs decreased REST and induced differentiation."
23483195
reach
"In contrast, HAUSP overexpression upregulates REST by overriding beta-TrCP-mediated ubiquitylation."
21258371
reach
"Theoretically, HAUSP might indirectly modulate REST through transcriptional control but we confirmed that HAUSP knockdown did not alter REST mRNA expression on RT-PCR analysis (XREF_FIG)."
21258371