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Curcumin inhibits KCNH2. 14 / 16
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"The liposomal curcumin formulation, at a curcumin concentration of 6muM, induced a statistically significant inhibition of the hERG tail current (30%) at I +20 (n = 3) (not included in figure)."
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"Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin."
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"In the present study, our formulation of lipopolymeric hybrid nanocurcumin formulation was conceptualized based on the protective effects of liposomes on curcumin dependent inhibition of the hERG current."
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"As shown in Fig. 2 A , curcumin dose-dependently inhibited hERG K + currents and the IC 50 value was 5.55 μM ( Fig. 2 B)."
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"Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K + channel at concentrations higher than the therapeutic concentrations of curcumin."
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"Taken together, the above data indicate that curcumin directly inhibits hERG K + channels in vitro ."
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"In order to identify whether the inhibition of hERG K + channels by curcumin came from its cytotoxic effect, we incubated the HEK293 cells expressing hERG channels with different concentrations of cur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although the inhibition of hERG K + channels by curcumin might not be directly related to its cytotoxic effect, its cytotoxic dose is close to that inhibiting hERG K + channels.Since curcumin inhibite[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Unfortunately, curcumin has been reported to block the hERG K + potassium channel [XREF_BIBR, XREF_BIBR]."
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"The manual patch clamp assay of HEK 293 cells clearly illustrated that this hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K + channel at concentrations higher than the therapeutic concentrations of curcumin."
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"Here, we found that curcumin potently inhibited hERG K + channels with an IC 50 of 5.5 μM in vitro ."
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"Studies revealed that curcumin inhibited the hERG K + channel in a concentration dependent manner with an IC 50 as low as 5.5 muM."
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"If curcumin inhibits hERG K + currents in vivo , it would prolong cardiac repolarization, manifested with QT interval prolongation."
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"In conclusion, curcumin inhibits hERG K + channels in vitro ."
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