IndraLab

Statements

Curcumin inhibits KCNH2. 11 / 12
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"In the present study, our formulation of lipopolymeric hybrid nanocurcumin formulation was conceptualized based on the protective effects of liposomes on curcumin dependent inhibition of the hERG current."
24330336
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"Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K + channel at concentrations higher than the therapeutic concentrations of curcumin."
24330336
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"The liposomal curcumin formulation, at a curcumin concentration of 6muM, induced a statistically significant inhibition of the hERG tail current (30%) at I +20 (n = 3) (not included in figure)."
24330336
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"In whole-cell patch-clamp experiments, we found that curcumin inhibited hERG K+ currents in HEK293 cells stably expressing hERG channels in a dose dependent manner, with IC50 value of 5.55 muM."
22101212
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"Curcumin inhibits hERG potassium channels in vitro."
22101212
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"The manual patch clamp assay of HEK 293 cells clearly illustrated that this hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K + channel at concentrations higher than the therapeutic concentrations of curcumin."
24330336
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"Studies revealed that curcumin inhibited the hERG K + channel in a concentration dependent manner with an IC 50 as low as 5.5 muM."
24330336
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"Unfortunately, curcumin has been reported to block the hERG K + potassium channel [XREF_BIBR, XREF_BIBR]."
24330336
ctd
No evidence text available
28551711
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"Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin."
23440458
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"We conclude that curcumin inhibits hERG K+ channels in vitro."
22101212