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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 inhibits Blood Pressure. 2 / 2

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"[XREF_BIBR - XREF_BIBR] More recent work in high-fat fed rats and mice indicated that impaired BK channel function contributes to elevated BP through increased tone in resistance arteries, and that reduced BK beta1-subunit expression plays a major role in obesity associated vascular dysfunction."

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"Interestingly, by the same measure, vascular BK channel deficiency tended to reduce sympathetic and increase parasympathetic drive of BP and HR in both control and high-fat fed mice."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...