IndraLab

Statements

USP7 activates Genomic Instability. 9 / 9
| 9
reach
"Collectively these data indicates that USP7 depletion causes genomic instability, one of the key hallmarks of cancer [XREF_BIBR]."
25003721
reach
"In this regard, Usp7 inhibition or depletion has been shown to impair cell cycle progression and proliferation also in a p53- independent manner by regulating genome stability and repair 69,88,89."
35673573
reach
"USP7 Depletion Causes Genomic Instability."
25003721
reach
"Collectively these data indicates that USP7 depletion may cause genomic instability, one of the hallmarks of cancer [XREF_BIBR]."
25003721
reach
"We observed that USP7 depletion induced genomic instability that may result from a change in stability of mitotic checkpoint proteins."
25003721
reach
"Geminin is important for genomic stability by binding chromatin licensing and DNA replication factor 1 (Cdt1) and preventing the formation of the pre-replicative complex, thereby inhibiting the premature entry of cells into the S phase Thus, USP7 deregulation can lead to DNA re-replication and genomic instability [23,30]."
38672118
reach
"In our study, we found that the simultaneous loss of RNF4 and USP7 significantly reduced DNA synthesis rate and increased genomic instability (figure 2)."
37607592
reach
"Depletion of USP7 in RNF4 knockouts reduces cell growth and increases genome instability."
37607592
reach
"Here, we found that USP7 depletion causes genomic instability characterized by abnormal chromosomes segregation, accumulation of micronuclei and increased aneuploidy."
25003721