IndraLab

Statements

UCHL1 increases the amount of HIF1. 4 / 4
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"Furthermore, genetic deletion or chemical inhibition of UCHL1 markedly reduced HIF1α levels under both normoxic and hypoxic conditions."
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"As shown in Figure 5F, inhibition of UCHL1 significantly reduced Hif-1α, but not the levels of Hif-1β and Hif-2α in the nucleus."
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"Finally, inhibition of UCHL1 promoted HIF-1alpha degradation and lowered the expression of HIF-1 target genes in the 3D model, as also observed in 2D monolayer culture."
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"Genetic deletion or chemical inhibition of UCHL1 reduced HIF1α levels in activated HSCs under both normoxic and hypoxic conditions, thereby strongly implicating UCHL1 as an important regulator of HIF expression and activity (Figure 6)."
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