IndraLab

Statements

INSR binds SLC2A1. 8 / 8
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"However, both IR isoforms associated with GLUT1 or GLUT2."
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"To address this relevant question, we crossed IR ∆GFAP with GLUT1 ∆GFAP mice to generate hGFAP-CreER T2+/− : Slc2a1 f/f : Insr f/f (named GLUT1-IR ∆GFAP ) mice, in which tamoxifen administration induces concomitant depletion of GLUT1 and IR exclusively from astrocytes ( xref )."
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"First, microdialysis experiments showed that GLUT1-IR ∆GFAP failed to increase brain ATP levels upon intraperitoneal glucose injection ( xref ) to the same extent as GLUT1 ∆GFAP mice."
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"Moreover, 18 F-FDG–PET studies revealed that GLUT1-IR ∆GFAP mice not only lacked the characteristic that enhanced 18 F-FDG signal present in GLUT1 ∆GFAP mice but also featured diminished brain glucose utilization similar to what is observed upon isolated IR deficiency ( xref , and fig."
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"Last, GLUT1-IR ∆GFAP mice failed to maintain the spatial memory acquisition ( xref ) and retention ( xref ) observed in GLUT1 ∆GFAP mice, in the absence of locomotor activity alterations (fig."
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"Provided that the effects of astrocytic IR reduction were rescued by acute intracerebroventricular administration of the 2-MeSATP, we decided to treat GLUT1-IR ∆GFAP mice with this same compound."
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"S9I) and HFD ( xref )] and the memory deficits shown by GLUT1-IR ∆GFAP mice [NCD (fig."
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"This revealed significant (ANCOVA P < 0.05, fold change > 5%) alterations in the expression of CD36 in CD4 + (FC = 1.64) and CD4 - /CD8 - (FC = 1.22) T cells and GLUT1 (FC = 0.68) and IR (FC = 1.11) i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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