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Protease leads to the deubiquitination of USP38. 1 / 1
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"Ubiquitin-specific protease 38 (USP38) was upregulated in the left atrium after aortic banding surgery.Cardiac-specific knockout of USP38 attenuated the atrial dilation and fibrosis and reduced the vulnerability of atrial fibrillation (AF) induced by pressure overload.Cardiac-specific overexpression of USP38 aggravated the atrial structural and electrical remodelling induced by pressure overload.Ubiquitin-specific protease 38 promoted atrial inflammation by interacting with and deubiquitinating nuclear factor-kappa B.Targeting USP38 may be an effective treatment for AF induced by pressure overload."
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