IndraLab

Statements

USP30 inhibits cell death. 4 / 4
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"In contrast, direct siRNA mediated depletion of MIRO2 to comparable residual levels marginally decreased PARP cleavage, whilst a combined knockdown of USP30 and MIRO2 promoted cell death in a similar fashion to USP30 siRNA on its own (XREF_SUPPLEMENTARY)."
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"In dopaminergic neurons, USP30 overexpression reduces rotenone -induced cell death, although it does not improve dopamine-treated cells [136]."
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"USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death."
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"In addition, overexpressing USP30, a mitochondrial deubiquitinase, attenuated cell death induced by Rot, but not by DA treated cells."
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