IndraLab

Statements

Glucocorticoid inhibits JUN. 6 / 6
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"It is thought that protein protein interactions similar to those described for GR-NF-kappaB are involved with GC inhibition of activator protein-1 (AP-1) and nuclear factor of activated T lymphocytes [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12909458
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"It was demonstrated that GC inhibit the assembly of c-Fos and c-Jun to form functional activator protein-1 [28]."
11306142
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"It is thought that protein–protein interactions similar to those described for GR–NF-κB are involved with GC inhibition of activator protein-1 (AP-1) and nuclear factor of activated T lymphocytes (NF-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12909458
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"Dexamethasone (DEX), a synthetic GC, was reported to inhibit the inflammatory response by downregulating the transcription factor AP-1 in human lung epithelial cells [XREF_BIBR]."
| PMC
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"8 The GC -GCR complex can also down-regulate inflammatory mediators such as cytokines, adhesion molecules, and enzymes, through effects on transcription factors such as nuclear factor kappa B (NFkB) and activator protein 1 (AP)-1. Steroids have been shown to alter the production of TNF and IL-6 by a specific effect at the mRNA level."
19474216
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"It is thought that protein–protein interactions similar to those described for GR–NF-κB are involved with GC inhibition of activator protein-1 (AP-1) and nuclear factor of activated T lymphocytes (NF-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12909458