IndraLab

Statements

COPS5 activates NFkappaB. 6 / 9
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"In their study, the authors found that depletion of CSN5 increased NF-kappaB activity."
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"However, Jab1 can activate NF-kappaB through Bcl-3 without forming a detectable complex with Bcl-3 and p50, suggesting that Jab1 transiently interacts with a complex of Bcl-3 and p50 [7]."
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"Mechanistically, Csn5 KO potentiated NF-kappaB signaling and proinflammatory cytokine expression in macrophages, whereas HIF-1alpha levels were reduced."
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"It has to be noted though that the effect of Csn5 and JAB1 on NF-kappaB seems to depend on the cell type and cellular context, as loss of JAB1 was also reported to reduce NF-kappaB activity, e.g. in thymocytes [XREF_BIBR] or synovial fibroblasts of rheumatoid arthritis patients [XREF_BIBR]."
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"Moreover, CSN5 silencing inhibited the secretion of TGF-beta, IL-1beta and IL-6 and the transcriptional activity of transcription factor NF-kappaB and Twist in human colorectal cancer cells."
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"Knock-down of Csn5 and JAB1 clearly enhanced basal NF-kappaB activity and improved cell survival under stress."
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