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USP46 ubiquitinates GRIA2. 1 / 1

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"By deubiquitinating K63 ubiquitinated glutaminergic AMPARs (α-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid) receptors GluA1 and GluA2, which are considered to mediate most of the excitatory synaptic transmission in the brain, USP46 upregulates the intracellular trafficking, cell surface density, and signal intensity of AMPARs [116,117]."

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USP46 ubiquitinates GRIA2. 1 / 1

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