IndraLab

Statements

USP18 inhibits immune response. 10 / 10
| 10
reach
"Ectopic expression of USP18 in tumor cells suppressed tumorigenesis and antitumor immune response whereas inhibition of USP18 expression promoted tumorigenesis and immunosurveillance."
24884733
reach
"USP18 enzymatic function typically attenuates the immune response by removing interferon-stimulated gene 15 (ISG15) from protein substrates."
37002195
reach
"Therefore, USP18 inhibits the immune response by reversing protein ISGylation and directly inhibiting IFN signaling pathway [ 39 ]."
35390466
reach
"USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response."
26713535
reach
"Significantly, higher infiltration of CD8 T cells was noted in these tumors, suggesting that the depletion of Usp18 in solid tumors can induce ICD and enhance the immune response."
38799433
reach
"Indeed, higher infiltration of CD8 T cells was observed in these tumors, suggesting that depletion of Usp18 in solid tumors can induce ICD and enhance the immune response (Supplementary Fig. 9c right)."
36646704
reach
"Based on these interesting findings, USP18 can attenuate the immune response even without dampening the type I IFN signaling.Finally, it has been reported that STAT1 transcriptional activity and NF-κB signaling activation, which regulate both the transcription and expression of ISGs, can be inhibited by SLFN5 and SLFN2, respectively [78,79]."
38932312
reach
"These results suggest that USP18 deletion leads to CSF1R downregulation in TAMs and a decrease in pro-tumor/immunosuppressive macrophages, contributing to enhanced anti-tumor macrophage polarization, consequently promoting a Th1-dominant TME and enhancing CD8 T cell-mediated anti-tumor immunity, in agreement with previous reports."
38100351
reach
"By modulating interferon signaling, USP18 can suppress the immune response to the transplanted ovarian tissue and thus reduce the risk of rejection."
38692177
reach
"These observations suggest that residual leukemia cells may upregulate USP18 expression as a protective mechanism against chemotherapy-induced death.Taken together, these results indicate that reduction of Usp18 expression potently suppresses cancer development and induces an anti-tumor immune response in vivo by a mechanism dependent on type I IFN signaling."
36646704