IndraLab

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COPS5 inhibits SMAD4. 8 / 9
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"Moreover, Jab1/CSN5 can induce the degradation of two important downstream molecules, Smad4 and Smad7, and affect transforming growth factor-b (TGFb) signaling which is also influenced by various factors in the tumor microenvironment, and might contribute to lymphatic and distant metastasis [7, 37]."
35870903
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"Besides, jun activation domainbinding protein 1 (Jab1), SCFSkp2, and SCFb-TrCP1 were reported to specifically promote degradation of Smad4 (Wan et al. 2002, 2004; Liang et al. 2004), whereas WWP2, SCF and Roc1 E3 ligase, and Nedd4L (see below) target R-Smads (Izzi and Attisano 2004; Gao et al. 2009; Soond and Chantry 2011)."
21913798
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"Jab1 and CSN5 induced Smad4 degradation results in reduced TGF-beta-mediated gene transcription, whereas its degradation of Smad7 leads to enhanced TGF-beta signaling effects [XREF_BIBR, XREF_BIBR]."
20955608
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"Examination of the effects of JAB1 induced Smad4 degradation indicates that Jab1 inhibited TGF-beta-induced gene transcription."
11818334
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"Importantly, JAB1 has been observed to interact with and induce degradation of SMAD4 [51]."
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"Jab1 induced Smad4 degradation results in reduced TGF-beta and BMP mediated gene transcription [XREF_BIBR]."
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"In fact, wild-type Smad4 can be degraded by the proteasome after polyubiquitination by the E3 ligase complexes Jab1 [83] and SCF βTrCP [84] ."
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"Jab1 can cause degradation of Smad4 via TGF-beta signal pathway, consequently contributing to the proliferation of PC cells."
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