IndraLab

Statements

COPS5 inhibits SMAD4. 6 / 6
1 | 5
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reach
"Jab1 induced Smad4 degradation results in reduced TGF-beta and BMP mediated gene transcription [XREF_BIBR]."
24078030
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reach
"Examination of the effects of JAB1 induced Smad4 degradation indicates that Jab1 inhibited TGF-beta-induced gene transcription."
11818334
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reach
"Importantly, JAB1 has been observed to interact with and induce degradation of SMAD4 [51]."
28923280
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reach
"Jab1 can cause degradation of Smad4 via TGF-beta signal pathway, consequently contributing to the proliferation of PC cells."
26464677
✎
signor
"We report a novel mechanism of smad4 degradation. Jab1 interacts directly with smad4 and induces its ubiquitylation for degradation"
11818334
✎
reach
"Jab1 and CSN5 induced Smad4 degradation results in reduced TGF-beta-mediated gene transcription, whereas its degradation of Smad7 leads to enhanced TGF-beta signaling effects [XREF_BIBR, XREF_BIBR]."
20955608