IndraLab

Statements

USP22 leads to the phosphorylation of RB1. 2 / 2
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"In pharyngeal carcinoma, knockdown of USP22 not only upregulated p21 expression but also upregulated p27 expression and suppressed retinoblastoma protein (RB) phosphorylation."
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"In vitro assays showed that USP22 depletion suppressed ATC cell survival and proliferation by decreasing Rb phosphorylation and cyclin D2, inactivating Akt, and simultaneously upregulating Rb; USP22 silencing restrained cell migration and invasion by inhibiting epithelial-mesenchymal transition; USP22 knockdown promoted mitochondrion- mediated and caspase dependent apoptosis by upregulating Bax and Bid and promoting caspase-3 activation."
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