IndraLab

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YOD1 activates coagulation. 2 / 2
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"Thus, the activation of NLRP3 inflammasome was limited in a proper intensity and time course to avoid coagulation.Our study highlighted the impact of YOD1 on the regulation of NLRP3 inflammasome-mediated coagulation activation."
38789414
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"In addition, YOD1-mediated coagulation in MRSA-induced sepsis was blocked by the administration of MCC950, a highly potent and specific inhibitor of NLRP3, which supported that YOD1-regulated NLRP3 inflammasome-dependent coagulation in the process of MRSA-induced DIC.In general, the deubiquitination of NLRP3 promotes its activation."
38789414