IndraLab

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Modified USP13 decreases the amount of PTEN. 2 / 2

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"Furthermore, USP13 overexpression induced phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and repressed the activation of AKT as well as the expression of the downstream effectors glucose transporter-1 (GLUT1) and hexokinase-2 (HK2)."

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"Overexpression of miR-130b/301b or USP13 knockdown by shRNA delivery decreases USP13 expression, and further reduces PTEN protein expression and leads to enhancement of cell proliferation, invasion and migration."

31200745

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IndraLab

Statements

Modified USP13 decreases the amount of PTEN. 2 / 2

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