IndraLab

Statements

USP11 activates TGFB1. 5 / 10
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"Three examples of deubiquitinating enzymes for TbetaR-I are ubiquitin specific peptidase-4 (USP4), -11 (USP11) and -15 (USP15), all of which antagonize the effect of SMAD7 and strongly induce TGF-beta1 signalling [XREF_BIBR]."
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"As USP11 promotes TGFbeta-1 signaling through stabilization of TbetaRII, we hypothesize that USP11 may have a critical role in the development of lung fibrosis."
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"De-ubiquitinating enzyme, USP11, promotes transforming growth factor beta-1 signaling through stabilization of transforming growth factor beta receptor II."
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"Here we reveal that a de-ubiquitinating enzyme, USP11, promotes TGFbeta-1 signaling through de-ubiquitination and stabilization of TbetaRII."
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"Consistent with their findings, we also revealed that USP11 promotes TGFbeta-1 signaling."
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