IndraLab

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Disulfiram inhibits USP25. 7 / 7
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"Notably, addition of a detergent, Triton X-100, showed no effect to the inhibitory function of disulfiram (Fig. S1), indicating the specificity of disulfiram-mediated inhibition.Next, to characterize [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results showed that pre-treatment of disulfiram diminished nearly 96% and 84% DUB activities of USP2 and USP21, respectively ( Fig. 4 )."
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"Additionally, disulfiram (DSF), an inhibitor against USP21 deubiquitylation activity, markedly abolished the USP21-mediated stability of G3BP1 protein and significantly displayed an anti-tumor effect on USP21-driving ESCC progression."
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"Next, to characterize the disulfiram-induced inhibitions of USP2 and USP21, kinetic measurements were carried out with a range of concentrations of inhibitor, and raw data were fitted to available inh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with the previous study in papain-like proteases, we found that the disulfiram-induced inhibitions of USP2 and USP21 were best fitted to the competitive inhibition model ( Fig. 2 )."
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"We also showed that disulfiram and 6TG can synergistically inhibit the activities of USP2 and USP21, suggesting a repurposing application of disulfiram and 6TG in treating USP-related tumors.The expre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recently, disulfiram and 6-thioguanine were reported to synergistically inhibit USP2 and USP21 but with low affinity in the micromolar range."
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