IndraLab

Statements

OTUD3 inhibits immune response. 5 / 5
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"OTUD3 specifically hydrolyzes Lys63-linked Ub of MAVS and thus represses innate antiviral immune response both in vitro and in vivo ."
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"Here, we show that OTUD3 inhibits the innate antiviral immune response to RNA viruses but promotes the innate antiviral immune response to DNA viruses, highlighting the complexity of innate antiviral [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Together, OTUD3 represses type I interferon expression and virus defense of cells dependent on its DUB activity.To investigate the role of OTUD3 in innate antiviral immunity in vivo , we generated Otu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"19 According to the study showing that OTUD3 associates with mitochondrial antiviral-signaling protein (MAVS) to suppress anti-RNA viral immune response, 17 we also performed coIP experiments using FL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This regulation of OTUD3 prevents innate antiviral immunity from unwanted auto- or extra-activation and meanwhile enables the efficient immune response against virus."
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