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3-hydroxybutyric acid inhibits NLRP3. 12 / 12
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"For example, the ketone metabolite beta-hydroxybutyrate mediates NLRP3 inflammasome inhibition in an ROS independent manner XREF_BIBR."
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"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease xref , xref and inhibits NF-κB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages. xref , xref Oxidation of the ketone body acetoacetate by liver-resident macrophage-like Kupffer cells reduces fibrosis in mouse models of high-fat liver injury. xref Whether this modulation of innate immune responses extends to alveolar macrophages and the lung, and whether ketone bodies would thereby slow the inflammation and fibrosis of ARDS, is an area for investigation."
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"Ketone body beta-hydroxybutyric acid (HBA) has a similar chemical structure as NaB and was also reported to inhibit NLRP3 activation [XREF_BIBR], and has been shown to decrease apoptosis of rat corneal epithelia in dry eye conditions [XREF_BIBR]."
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"Furthermore, beta-hydroxybutyrate inhibits NLRP3 inflammasome in lipopolysaccharides (LPS)-stimulated human monocytes resulting in the reduction of IL-1beta and IL-18 in a dose dependent manner [XREF_BIBR]."
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"For example, the ketone body, b-hydroxybutyrate, which specifically inhibits NLRP3 inflammasome activation via potassium efflux blockade, and the naturally derived antioxidant, sulforaphane, have been shown to attenuate MSU induced responses in murine models of gout."
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"In human monocytes beta-hydroxybutyrate was recently shown to inhibit NLRP3 inflammasome, responsible for activation of caspase-1 and the release of the pro inflammatory cytokines IL-1beta and IL-18."
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"However, beta-hydroxybutyrate inhibited NLRP3 inflammasome in macrophages such as immune response [XREF_BIBR]."
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"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease38 , 40 and inhibits NF-κB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages."
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"Recently, one of the ketone bodies, beta-hydroxybutyrate, was shown to specifically inhibit NLRP3 inflammasome [XREF_BIBR] and synthetic compound MCC950 demonstrated effective and specific NLRP3 inflammasome inhibition with promising results in the mouse model of CAPS [XREF_BIBR]."
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"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."
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"Beta-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares."
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"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease 38,40 and inhibits NF-kB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages."
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