IndraLab

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3-hydroxybutyric acid inhibits NLRP3. 18 / 18
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"The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasomemediated inflammatory disease."
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"A recent exciting report from these authors shows that BHB inhibits NLRP3 in macrophages in vitro as well as in mouse models of cryopyrinopathy in vivo ."
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"The Ketone Body beta-Hydroxybutyrate Inhibits NLRP3 Inflammasome-Mediated Inflammation."
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"Recently, one of the ketone bodies, beta-hydroxybutyrate, was shown to specifically inhibit NLRP3 inflammasome [XREF_BIBR] and synthetic compound MCC950 demonstrated effective and specific NLRP3 inflammasome inhibition with promising results in the mouse model of CAPS [XREF_BIBR]."
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"For example, the ketone metabolite beta-hydroxybutyrate mediates NLRP3 inflammasome inhibition in an ROS independent manner XREF_BIBR."
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"Beta-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares."
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"However, beta-hydroxybutyrate inhibited NLRP3 inflammasome in macrophages such as immune response [XREF_BIBR]."
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"Furthermore, beta-hydroxybutyrate inhibits NLRP3 inflammasome in lipopolysaccharides (LPS)-stimulated human monocytes resulting in the reduction of IL-1beta and IL-18 in a dose dependent manner [XREF_BIBR]."
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"Beta-Hydroxybutyrate reverses podocyte changes in Nphs2-Cre; Nlrp3 WT/A350V mice."
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"In human monocytes beta-hydroxybutyrate was recently shown to inhibit NLRP3 inflammasome, responsible for activation of caspase-1 and the release of the pro inflammatory cytokines IL-1beta and IL-18."
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"Beta-Hydroxybutyrate (BHB), 1 of the ketone bodies, reduces the proinflammatory NLR family pyrin domain containing 3 inflammasomes, as well as chemokines in cultures."
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"Beta-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares."
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"Beta-hydroxybutyric acid has been shown to inhibit NLRP3 macrophage inflammasome activation."
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"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease xref , xref and inhibits NF-κB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages. xref , xref Oxidation of the ketone body acetoacetate by liver-resident macrophage-like Kupffer cells reduces fibrosis in mouse models of high-fat liver injury. xref Whether this modulation of innate immune responses extends to alveolar macrophages and the lung, and whether ketone bodies would thereby slow the inflammation and fibrosis of ARDS, is an area for investigation."
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"For example, the ketone body, b-hydroxybutyrate, which specifically inhibits NLRP3 inflammasome activation via potassium efflux blockade, and the naturally derived antioxidant, sulforaphane, have been shown to attenuate MSU induced responses in murine models of gout."
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"Ketone body beta-hydroxybutyric acid (HBA) has a similar chemical structure as NaB and was also reported to inhibit NLRP3 activation [XREF_BIBR], and has been shown to decrease apoptosis of rat corneal epithelia in dry eye conditions [XREF_BIBR]."
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"Moreover, the most abundant ketone body, beta-hydroxybutyrate, inhibits the NLRP3 inflammasome in myeloid cells, a key potentiator of age-related inflammation."
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"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."
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