IndraLab

Statements

BAP1 activates asbestos. 4 / 4
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"In mouse models, inactivation of only one BAP1 allele increases asbestos tumorigenicity."
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"Currently, the available human data leans toward the notion that germline mutations (BAP1 and others) may induce mesothelioma independent of asbestos exposure (Attanoos et al., 2018)."
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"Mutations in BAP1, detected in 30-60% of MPM cases, accelerate asbestos-induced MPM in mice [1]."
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"The fact that we determined that highly penetrant, heterozygous pathogenic BAP1 null variants by themselves, as studied by Kadariya et al. , can initiate and drive MM tumorigenesis in mice absent asbestos exposure supports their conclusions, in agreement with Chanock ."
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