IndraLab

Statements

USP35 decreases the amount of Interferon. 2 / 2
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"Knockdown of USP35 combined with oncolytic virus significantly promotes the immune infiltration of CD8+ T cells and the release of IFNβ and inflammatory factors CXCL10 and CCL5, ultimately inhibiting the growth of malignant melanoma, Overall, our findings identify USP35 as a previously undescribed regulator of MAVS pathway, and targeting USP35 provides a strategy for immunotherapy of malignant melanoma."
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"We used 3pRNA to activate RIGI/MAVS signaling and found that the mRNA expression level of IFNβ, CXCL10, and ISG15 was significantly enhanced by USP35 depletion (Fig. 2G)."
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