IndraLab

Statements

CYLD inhibits TGFB. 15 / 18
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"This study proposes that CYLD inhibits TGFbeta signalling by decreasing the stability of SMAD3 via the AKT-GSK3-CHIP pathway."
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"CYLD negatively regulates TGFbeta responsiveness, adversely affecting extrathymic Treg induction and the pTreg pool."
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"Lim and co-workers showed that CYLD suppresses TGF-beta signalling and prevents lung fibrosis by (indirectly) reducing the stability of Smad3, in an AKT, GSK3beta and E3 ligase carboxy terminus of Hsc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD deubiquitinates Smad7 and inhibits TGF-beta signaling ( 58 ) ."
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"A study found that the loss of CYLD stabilized TGF-βRI by removing the k63-linked polyubiquitin chain on SMAD7, and consequently promoted TGF-β signaling in OSCC cells (108)."
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"After Streptococcus pneumoniae infection, CYLD deficiency results in the development of lung fibrosis in mice, with enhanced TGF-β signaling."
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"Finally, the deubiquitylase CYLD inhibits TGF-beta signaling by decreasing the stability of Smad3."
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"CYLD inhibits TGF-β signaling and prevents mice from lung fibrosis by deubiquitinating K63-linked polyubiquitinated Akt, leading to impairment of Smad3 stability."
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"CYLD also can negatively regulate TGF-β signaling which is involved in the generation of pTreg cells."
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"The deubiquitylating enzyme CYLD additionally inhibits TGF-beta signaling by forming a complex with Smad7 and facilitates its deubiquitylation at two sites in its MH2 domain."
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"The knockdown of CYLD stimulates TGF-β signaling by maintaining ALK5 stabilization in a cell-autonomous fashion."
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"A deficiency of CYLD causes constitutive NF-kB activation and enhanced TGF-b signaling, which increases the frequency of Treg cells in peripheral lymphoid organs and promotes Treg cell differentiation in vitro (149, 150)."
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"It is interesting that CYLD knockdown promoted transforming growth factor-beta (TGF-beta) signalling by inducing stabilization of TGF-beta receptor I (ALK5) in a cell autonomous fashion."
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"CYLD also negatively regulates signaling and TGFbeta responsiveness, suppressing extrathymic Treg induction and the pTreg pool."
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"CYLD inhibits the Wnt/β-catenin and TGF-β signaling pathways by regulating the Lys63-linked ubiquitination of ALK5, thereby suppressing tumor growth and cell invasion246 247."
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