IndraLab

Statements

PRKN inhibits USP30. 4 / 4
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"Interestingly, while parkin overexpression also suppressed the USP30 overexpression phenotype as expected (S3D Fig), other Ub-ligases linked to mitophagy, Mul1 and March5 [39,43–47], showed no suppression of this phenotype (S3D Fig)."
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"A CHX assay showed that overexpression of Parkin strongly decreased the half-life of the exogenous USP30 protein (Fig. 6b)."
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"Bingol and colleagues first reported that USP30 antagonises Parkin mediated mitophagy [XREF_BIBR]."
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"One potential explanation for no effect on the feed-forward process with overt depolarization is that activated Parkin rapidly inactivates USP30 or otherwise outpaces Ub removal by USP30, as previously proposed."
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