IndraLab

Statements

Phosphorylated IRS1 decreases the amount of IRS1. 3 / 3
| 3
reach
"First, mTORC1 is negatively regulated by its downstream substrate S6K via the phosphorylation of IRS1 and reduction in the IRS1 protein level."
37582972
reach
"Elevated Ser/Thr IRS-1 phosphorylation may inhibit insulin signalling by (1) downregulating IRS-1 protein levels through ubiquitination [XREF_BIBR - XREF_BIBR], (2) inhibiting the interaction between the tyrosine phosphorylated IR and the phosphotyrosine binding (PTB) domain of IRS-1 [XREF_BIBR - XREF_BIBR], or (3) interfering with the insulin stimulated interaction between IRS-1 and its downstream partner, the phosphatidylinositol 3-kinase (PI3-K) adaptor molecule p85 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
21850561
reach
"The phosphorylation of IRS-1 promotes IRS-1 degradation and reduces IRS-1 expression, leading to decreased activity of PI3K and Akt."
19694499