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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Phosphorylated IRS1 decreases the amount of IRS1. 2 / 2

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"The phosphorylation of IRS-1 promotes IRS-1 degradation and reduces IRS-1 expression, leading to decreased activity of PI3K and Akt."

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"Elevated Ser/Thr IRS-1 phosphorylation may inhibit insulin signalling by (1) downregulating IRS-1 protein levels through ubiquitination [XREF_BIBR - XREF_BIBR], (2) inhibiting the interaction between the tyrosine phosphorylated IR and the phosphotyrosine binding (PTB) domain of IRS-1 [XREF_BIBR - XREF_BIBR], or (3) interfering with the insulin stimulated interaction between IRS-1 and its downstream partner, the phosphatidylinositol 3-kinase (PI3-K) adaptor molecule p85 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...