The INDRA Database

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"We propose that cytosolic ROS and RNS inhibit the NLRP3 inflammasome and that PCN 's anti-inflammatory activity may help P. aeruginosa evade immune recognition."

29414783

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"ROS scavenger dissociates TXNIP from NLRP3, and inhibits NLRP3 inflammasome activation in cardiac microvascular endothelial of C57BL/6J mice with simulated ischemia and reperfusion injury XREF_BIBR."

27270216

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"TRIM30 knockdown increases ROS production, which enhances NLRP3 inflammasome activation."

25324778

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"A recent study showed that ROS inhibitor such as DPI abolished IL-1beta release in mouse macrophages by inhibiting NLRP3 gene expression XREF_BIBR."

24223129

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"Treatment with ribavirin decreases the expression of reactive oxygen species (ROS) in lung tissue, downregulates IL-1β and IL-18 levels, and inhibits the activation of NLR family pyrin domain containing 3 (NLRP3) inflammatory bodies ."

34531754

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"Interruption of ROS production with pharmacological inhibitors blocks activation of the Nlrp3 inflammasome, suggesting that the generation of ROS is a required upstream event for Nlrp3 activation."

23954133

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"Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mitochondrial reactive oxygen species (mtROS)."

35437791

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"Previous studies demonstrated that reactive oxygen species (ROS) was a necessary step for NLRP3 activation, and inhibition ROS production by ROS inhibitor suppressed NLRP3 inflammasome activation."

29163015

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"NLRP3 inflammasome activation by decreased ROS through mitophagy might play a crucial role in berberine (BBR)-mediated alleviation of IV induced inflammatory lesions [XREF_BIBR]."

| PMC

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"Recently, it has been reported that ROS derived iNOS inhibits NLRP3 inflammasome activity."

30214444

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"Nodakenin alleviates renal ischemia-reperfusion injury via inhibiting ROS induced NLRP3 inflammasome activation."

32902019

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"Specifically, the antioxidant properties of polyphenols outlined in Section Polyphenol Compounds as Free Radical Scavengers identify them as potential inhibitors of ROS mediated NLRP3 activation."

30210334

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"Nigericin-mediated ASC speck formation and cytokine secretion was reduced with either inhibitor , showing that ROS production and / or cathepsin activity can activate NLRP3 ( Fig. 6B ) ."

33380493

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"Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress."

26102024

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"Taken together, these data suggest that Epac1 and PKA reduce retinal inflammation through the reduced ROS-induced activation of NLRP3 pathway proteins."

37089701

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"Moreover, a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM), abrogated mtROS release, inhibited NLRP3 inflammasome activation and reduced the up-regulation of IL-1beta and IL-18 induced by ethanol or lipopolysaccharide (LPS)/ATP."

30873011

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"Oxidative stress is considered an important driver of NLRP3 inflammasome activation, and ROS scavenging can attenuate NLRP3 inflammasome activation [XREF_BIBR]."

32064027

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"Although a low level of ROS promotes NLRP3 inflammasome activation, a recent study demonstrated that a high level of ROS generated by Streptococcus pneumonia infection inhibited the NLRP3 inflammasome through the oxidation of the inflammasome components ASC and caspases [30]."

31979265

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"Furthermore, our data indicated that a ROS scavenger can significantly prevent Nlrp3 inflammasome activation and cytokine release during albumin stimulation, indicating that redox signalling drives Nlrp3 activation."

25281528

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"However, recent findings that elimination of ROS by antioxidants suppressed activation of NLRP3 inflammasome and the resultant maturation of IL-1beta have shed new light on understanding the roles of antioxidants in pathogenesis of inflammation related diseases [XREF_BIBR]."

25214720

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"In vitro, ROS upregulated neuronal pyroptosis and activated the NLRP3 inflammasome pathway, both of which were reversed by addition of a ROS scavenger."

32891159

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"ROS mediated NLRP3 inflammasome axis can be a potential therapeutic target for neosporosis."

32891167

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"In addition, downregulated serum IL-1beta and IL-18, as well as dampened activity of caspase-1 in liver homogenates of NAC pretreated mice indicated that scavenging ROS actually inhibited NLRP3 inflammasome activation."

29692782

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"Moreover, the scavenging ROS relieved the autophagy, NLRP3 inflammasome activation and pyroptosis."

30205151

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"Interruption of ROS production by pharmacological inhibitors or scavengers inhibit NLRP3 inflammasome activation in response to many, if not all, previously evaluated activators, suggesting that ROS generation is a common upstream event required for NLRP3 activation."

26081624

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"Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO mediated NLRP3 inflammasome activation was dependent on ROS."

33074353

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"We also observed the inhibition of ROS mediated NLRP3 activation, as well as the decrease of NF-kappaB p65 nuclear translocation and its downstream inflammatory cascades."

30805082

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"In view of this evidence, we demonstrated that the activation of autophagic flux by melatonin inhibited ROS producing NLRP3 dependent inflammasome and reduced the inflammatory response."

33353046

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"In addition, it still remains a mystery as to what molecule (s) are targeted by ROS to enhance NLRP3 inflammasome activation."

21884179

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"Treatment with ribavirin decreases the expression of reactive oxygen species (ROS) in lung tissue, downregulates IL-1β and IL-18 levels, and inhibits the activation of NLR family pyrin domain containing 3 (NLRP3) inflammatory bodies (Chen et al., 2020)."

34531754

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"And Pae decrease the ROS generated, restore mitochondrial membrane potential (ΔΨm), inhibit M1 macrophage polarization and NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs) in vitro."

35182973

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"Some investigators have suggested that signaling by ROS drives NLRP-3 inflammasome formation, while others reported that an inducer of ROS can inhibit NLRP-3 inflammasome activation."

29067455

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"Oltipraz, the activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS-mediated NLRP3 inflammasome."

36336010

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"Autophagy Inhibition Contributes to ROS Producing NLRP3 Dependent Inflammasome Activation and Cytokine Secretion in High Glucose Induced Macrophages."

28854426

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"Intriguingly, the ROS induced NLRP3 inflammasome up-regulation was suppressed by NF-kB inhibitor, which indicated NF-kB was an essential link between ROS and NLRP3 inflammasome."

25136835

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"Therefore, ROS induced NLRP3 inflammasome activation is potentially a novel target for the prevention and treatment of CMV associated SNHL."

29512778

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"Additionally, mitochondrial ROS (mtROS) scavenger mito-TEMPO abolished NLRP3 inflammasome activation in IH treated RAW264.7 cells."

32066884

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"Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R treated cells, and suppressed ER stress induced NLRP3 inflammasome activation."

29662437

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"Indeed, ROS is identified as a potent endogenous ligand for NLRP3, since the early reports has demonstrated that the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced ROS inhibited NLRP3 activation in macrophages treated with ATP (Cruz et al., 2007); meanwhile, the absence of the p22phox subunit within NADPH oxidase substantially attenuated IL-1β production when macrophages exposed with asbestos (Dostert et al., 2008)."

30405440

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"We reported previously that high glucose and lipopolysaccharide activate ROS-TXNIP-NLRP3 inflammasome signaling in GMCs, but ROS inhibitor N-acetylcysteine (NAC) could not completely inhibit the activation of NLRP3 inflammasome induced by high glucose, suggesting that there may be other pathways by which high glucose primes ROS-NLRP3 inflammasome signaling [XREF_BIBR]."

29675433

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"Interruption of ROS production using inhibitors blocks NLRP3 activation, suggesting ROS production upstream is necessary for NLRP3 activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

29120406

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"Inhibition of mitochondrial complex I by rotenone or complex III by antimycin A induces robust mitochondrial ROS production, which drives NLRP3 inflammasome activation."

28729463

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"In BV2 cells, the application of NAC further demonstrated that HS could effectively inhibit the expression of the ROS-activated NLRP3 inflammasome."

37371417

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"Our recent results showed that ROS scavenging by anti-oxidants such as NAC or mito-TEMPO inhibits priming and activation of NLRP3, whereas induction of mitochondrial ROS (mtROS) by rotenone can lead to its potent priming and activation."

24048902

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"It has been demonstrated that a low level of ROS positive regulate the priming signal of the NLRP3 inflammasome and promote NLRP3 inflammasome activation; however, Erttmann and Gekara demonstrated that a high level of ROS release by Streptococcus pneumonia increased the oxidative levels of the inflammasome components ASC and caspases and inhibited the NLRP3 inflammasome."

33424855

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"The use of ROS scavenger N-acetylcysteine (NAC) partially reversed NLRP3 inflammasome activity in cells exposed to burn serum."

26576075

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"Further experiments demonstrated that the QDs induced mitochondrial reactive oxygen species (mtROS) production, and that both a mtROS and a total ROS scavenger attenuated QDs induced NLRP3 activation and pyroptosis."

26986854

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"Scavenging of ROS blocks NLRP3 inflammasome activation in response to a wide variety of stimuli."

25356867

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"Disruption of glycolytic flux led to an NAD +/NADH imbalance and induced mitochondrial ROS accumulation, which has been shown here and elsewhere to activate the NLRP3 inflammasome (XREF_FIG)."

27011353

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"Similarly, inhibitors of ROS production or scavengers of ROS, including NAD (P) H oxidase inhibitors can suppress NLRP3 activation."

25338942

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"These findings demonstrate that cyanidin acyl glucosides and peonidinacyl glucosides inhibit senesce by suppressing ROS levels and deactivating the NLRP3 inflammasome [34,35]."

32650482

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"Thus, our findings suggest that moderate ROS levels act as triggers for the NLRP3 inflammasome in line with the known role of mitochondrial ROS released from stressed mitochondria (Latz et al., 2013; Zhou et al., 2011), while excessive ROS levels display an opposite effect and inhibit NLRP3 activation."

32096759

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"In a study of male hyperoxaluric rats, inhibition of the transient receptor potential vanilloid 1 channel, which functions upstream of NLRP3, mitigated reactive oxygen species-induced NLRP3 activation and calcium oxalate-induced nephropathy but did not reduce hyperoxaluria ."

36329260

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"Conversely, a ROS scavenger that dissociates Txnip from NLRP3 inhibits the activation of NLRP3 inflammasome in microvascular endothelial cells."

27807222

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"Finally, RSV and Japanese encephalitis virus (JEV) have both been found to induce NLRP3 activation through K + efflux from the cell and ROS production as treatment with K + buffered medium or the ROS inhibitors APDC or diphenyleneiodonium chloride (DPI) inhibited NLRP3 inflammasome activation."

23947344

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"Here we demonstrate that a known potent inducer of ROS can also inhibit NLRP3 inflammasome activation."

24337744

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"Therefore, to analyze the ROS regulation of NLRP3 inflammasome in brain I/R injury, we chose 250 mg/kg of NAC and 500 nmol of ATP as the optimum dose and concentration, respectively, for further study.We analyzed ROS levels in OE-Nrf2 and sh Nrf2 of rat MCAO models and determined the role of ROS in Nrf2-induced NLRP3 inflammasome inhibition."

35434015

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"Unexpectedly, knockdown of NCLX induced ROS generation and increased activation of the NLRP3 inflammasome."

26089852

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"In a word, these findings demonstrate that AS pretreatment attenuated RIR mediated ALI potentially through reducing ROS induced activation of the NLRP3 inflammasome."

29730819

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"Nlrp3 activation is blocked by ROS scavengers and NAPDH oxidase inhibitors 65."

22430785

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"In addition , NLRP3 ( pyrin domain containing protein 3 ) as a downstream effector of ROS in M1-polarized macrophage , was significantly suppressed following TRPV4 inhibition ."

36552524

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"While scavenging of ROS by NAC also attenuated liver inflammation, NLRP3 inflammasome activation and IL-1beta production, indicating an important role of ROS in mediating NLRP3 inflammasome activation in experimental AIH."

29692782

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"Moreover, possibly by partly inhibiting ROS-mediated NLRP3 inflammasome-induced pryoptosis."

32782443

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"Moreover, ROS was required for E. coli O157 : H7 induced NLRP3 assembly as inhibiting mitochondrial ROS release by ROS scavengers Mito-TEMPO and N-acetylcysteine abrogated NLRP3 inflammasome activation in Caco-2 cells in response to E. coli O157 : H7."

28476502

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"ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs."

25015733

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"CST knockout exaggerated mitochondrial ROS dependent activation of the NLRP3 inflammasome."

32550919

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"The administration of a non-specific ROS scavenger, PBN, markedly alleviated mechanical allodynia and inhibited the activation of NLRP3 inflammasome in DRGs and sciatic nerve of the paclitaxel-induced neuropathic pain model.Chemotherapy-induced pain is the most common treatment-limiting complication encountered by cancer patients receiving taxane-, vinca alkaloid-, or platin-based chemotherapy."

28714351

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"The ROS inhibitors or scavengers inhibit the function of the NLRP3 inflammasomes, and the mitochondrial-derived ROS is pivotal in the activation of NLRP3 inflammasomes [40]."

34266474

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"Cells were pretreated for 1h prior to stimulation with 1 microM MCC950 or 25 microg/ml glybenclamide to inhibit NLRP3 activation, 10 microM DPI to inhibit cellular reactive oxygen species (ROS) production, 100 microM cathepsin inhibitor Ca-047-Me or indicated amounts of the pan-caspase inhibitor z-VAD-fmk."

33380493

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"ROS have been shown to activate the inflammasome in MI/R injury [XREF_BIBR, XREF_BIBR], ROS generation has been identified as an important mechanism by which NLRP3 inflammasome is activated, and NLRP3 activation was blocked by ROS scavengers [XREF_BIBR]."

29062465

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"Inhibition of mitochondrial complex I-induced- ROS impairs NLRP3 inflammasome activity [46], and impaired monocyte NLRP3 activity is associated with mitochondrial dysfunction and increased risk of death in sepsis [47]."

31996961

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"In rats fed with fructose, cinnamaldehyde represses cardiac fibrosis by supressing oxidative stress and ROS production, thereby inhibiting NLRP3 inflammasome activation via the CD-36-mediated TLR4/6-IRAK 4/1 signaling pathway."

33390969

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"More importantly, ROS specific inhibitor NAC prevented fructose induced alteration of NLRP3 and IL-1beta, as well as TGF-beta, p-Smad2/3 and Smad4 in H9c2 cells (XREF_FIG)."

27270216

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"ROS inducer PG inhibited N. caninum replication by promoting NLRP3 inflammasome activation in vitro."

32891167

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"While many activators of the NLRP3 inflammasome generate ROS, the interruption of ROS production with pharmacological inhibitors can block the activation of NLRP3."

30873162

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"Our compound, procyanidins, as a ROS scavenger, significantly inhibited the morphine-induced release of ROS and then suppressed the microglial NLRP3 inflammasome to attenuate morphine tolerance (Fig. 6)."

26931361

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"The administration of a non-specific reactive oxygen species scavenger, phenyl-N-tert-butylnitrone, markedly alleviated mechanical allodynia and inhibited the activation of NLRP3 inflammasome in L4-6 dorsal root ganglia and sciatic nerve of the paclitaxel-induced neuropathic pain model."

28714351

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"We used siRNA to knockdown MINK1 in the human THP-1 cell line (Fig. S6C) and found that ROS scavenging reduced NLRP3 activation only in the control group but not in MINK1 knockdown cells (Fig. 6I)."

34480147

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"ALDH2 can reduce the multiple sources of ROS, such as oxidative stress, inflammation, and mitochondrial damage, thereby reducing the activation of NLRP3 inflammasome."

36910525

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"Pathophysiological changes mediated by mitochondria including the imbalance in mitochondrial dynamics and the release of cytochrome c, mitochondrial DNA or reactive oxygen species (ROS) can either activate or inhibit the NLRP3 inflammasome [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."

30096906

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"Scavenging of ROS by N-acetyl-cysteine also attenuated NLRP3 inflammasome activation and liver inflammation, indicating that the essential role of ROS in mediating NLRP3 inflammasome activation in ConA induced hepatitis."

29692782

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"As mitochondria and ROS are critical for NLRP3 inflammasome activation [69,70], we showed that melatonin blocked morphine-induced NLRP3 inflammasome in vitro and in vivo by decreasing the generation of ROS level and CTSB release, which were reported to activate NLRP3 [53,54,66,71,72] and suppress morphine antinociceptive tolerance [73]."

32413745

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"Furthermore, experiments indicated that MSNs induced mitochondrial reactive oxygen species (ROS) generation, and the ROS scavenger could attenuate the MSN activated NLRP3 inflammasomes and pyroptosis in the liver."

29722780

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"Blockade of MR with EPL significantly prevented mitochondrial ROS production and activation of the NLRP3 inflammasome."

27014913

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"Methods : Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/-) mice."

32009974

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"These results suggest that Nrf2 regulates NQO1 to attenuate ROS, which negatively regulates NLRP3 inflammasome."

35434015

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"Some debate exists on what type of ROS is important for NLRP3 activation as ROS scavengers and inhibitors strongly impede NLRP3 activation."

24829412

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"These data are relevant because it has been reported that ROS induced TXNIP-NLRP3 association, and TXNIP deficiency inhibited ROS mediated NLRP3 inflammasome activation 18."

23838164

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"Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation."

37464384

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"The ROS inhibitor, N-acetyl-l-cysteine, exerted a protective effect on the UA induced apoptosis of tubular epithelial cells by reducing excess ROS production, which significantly inhibited NEK7 and NLRP3 inflammasome activation."

34414459

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"Recent findings that elimination of ROS by antioxidants suppressed activation of the NLRP3 inflammasome and the resultant maturation of IL-1beta have shed new light on understanding the roles of antioxidants in the pathogenesis of inflammation related diseases XREF_BIBR."

27917949

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"In conclusion, H 2 S ameliorates the toxic effects of PQ on the liver by enhancing antioxidative capability, regulating mitochondrial function, and suppressing ROS induced NLRP3 inflammasome activation."

32064027

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"Since ROS scavengers attenuate NLRP3 activation, the generation of ROS was considered a common cellular response critical for NLRP3 activation."

33716981

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"ROS act as signaling molecules and regulate metabolism, proliferation XREF_BIBR and inflammation, as indicated by the fact that either deficiency in NADPH oxidase (an enzymatic ROS source) or the presence of antioxidants inhibit NLRP3 inflammasome activation XREF_BIBR."

28084303

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"The lysosomal NADPH oxidase appeared to be a good candidate for the source of ROS and silencing NADPH oxidase reduced NLRP3 activation by asbestos and MSU."

25879282

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"Researchers demonstrated that Nrf2 inhibition of ROS induced NLRP3 priming required the participation of NAD (P) H quinone dehydrogenase 1 (NQO1) [XREF_BIBR]."

32655760

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"ROS induced NLRP3 activation was diminished by the knocking-down of voltage dependent anion channel-1, which is tightly regulated by Bcl-2."

25879294

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"Moreover, intracellular ROS and RNS were sufficient to inhibit activation of NLRP3."

29414783

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"PCN induced intracellular ROS and RNS inhibited the NLRP3 inflammasome posttranslationally, and hydrogen peroxide or peroxynitrite alone were sufficient to block its activation."

29414783

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"Inhibition of NADPH oxidase dependent ROS production has been previously suggested to occur upstream of NLRP3 inflammasome activation, and accumulation of ROS producing mitochondria by rotenone, a pha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

25461402

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"NLRP3 activation can be blocked by ROS scavengers XREF_BIBR."

25136835

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"Thus, the ROS removal via autophagy regulation can prevent aberrant activation of NLRP3 inflammasome [19]."

35047046

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"ROS scavengers or knockdown of NADPH oxidase can inhibit the NLRP3 inflammasome XREF_BIBR, XREF_BIBR."