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TNFAIP3 activates Cell Survival. 4 / 4
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"This signature of EGFR TKI induced NF-kappaB output consisted of 36 NF-kappaB target genes, including established regulators of NF-kappaB signaling and cell survival such as TNFAIP3, BIRC3, and IL6 (XREF_FIG and XREF_SUPPLEMENTARY)."
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"This paper focuses on the latter one.LMP-1 increases cell viability by up-regulation of anti-apoptotic protein: Bcl-2, Mcl-1, Bcl-2-related protein A1 (Bcl-2A1), and tumor necrosis factor (TNF) alpha-induced protein 3 (TNFAIP3)/A20."
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reach
"Activation of canonical NF-κB in response to EGFR oncogene inhibition in mutant EGFR-bearing human and mouse lung cancer cells, drives tumour cell survival and residual disease in lung cancer via several established regulators of canonical NF-κB signalling and cell survival such as TNFAIP3 (TNFα-induced protein 3), BIRC3 (c-IAP2, TNFR2-TRAF signalling complex protein) and IL-6 [16]."
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"TNFAIP3 , an important anti-inflammatory factor , can repress the expression of inflammatory NF-kappaB signaling and promote cell survival ( Catrysse et al ., 2014 ) ."
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