IndraLab

Statements

EZH2 activates BAP1. 4 / 4
| 4
reach
"In BAP1-deficient human mesothelioma cells, EZH2 inhibition also produced synthetic lethality ."
30030490
reach
"Inactivation of BAP1 sensitises tumour cells to EZH2 inhibition, which has been shown to substantially inhibit tumour growth in BAP1 -deficient malignant pleural mesothelioma mouse models."
35588752
reach
"Interestingly, EZH2 depletion by both genetic and pharmacologic methods abrogated the oncogenic effect of BAP1 loss."
32206160
reach
"EZH2 inhibition in combination with ZA limits tumor growth and prolongs survival of Bap1-deficient mesothelioma mice."
36657447