Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP2 inhibits NFkappaB. 2 / 3

| 2

➶

reach

"The ubiquitin #specific proteases system 2 (USP2) stabilizes the ubiquitin-E3-ligase ITCH and lowers NF-kappaB basal activity, which leads to reduced c-FLIP mRNA production; proteasomal degradation of c- FLIP isoforms is also elevated by its negative regulator proteasome ITCH [XREF_BIBR]."

32352084

➶

reach

"USP2a, a 69-kDa splice variant of USP2, also known as USP9 and UBP41, negatively regulates NF-kappaB activation and proinflammatory cytokine production by interacting with TRAF6."

33138315

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...