IndraLab

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USP2 inhibits NFkappaB. 2 / 3
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"The ubiquitin #specific proteases system 2 (USP2) stabilizes the ubiquitin-E3-ligase ITCH and lowers NF-kappaB basal activity, which leads to reduced c-FLIP mRNA production; proteasomal degradation of c- FLIP isoforms is also elevated by its negative regulator proteasome ITCH [XREF_BIBR]."
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"USP2a, a 69-kDa splice variant of USP2, also known as USP9 and UBP41, negatively regulates NF-kappaB activation and proinflammatory cytokine production by interacting with TRAF6."
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