IndraLab

Statements

HTT inhibits ATXN3. 6 / 6
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"Our data indicate that the N-terminal fragment of polyQ-expanded (PQE) Atx7 or Htt can coaggregate with and sequester AR and Atx3 into insoluble aggregates or inclusions through their respective polyQ tracts."
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"PQE Atx7 and Htt reduce the soluble fraction of endogenous Atx3 but increase its insoluble aggregates."
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"Thus, the N-terminal fragment of PQE Atx7 or Htt can sequester endogenous AR and Atx3 into aggregates via a coaggregation process."
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"Our supernatant/pellet fractionation and immunofluorescence images confirmed that the fragment of PQE Atx7 or Htt can sequester AR and Atx3 into aggregates in cells."
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"PQE Atx7 and Htt promote proteasomal degradation of intracellular Atx3."
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"In the present study, to address the molecular mechanism underlying the coaggregation of polyQ proteins, we applied four polyQ-containing proteins (AR, Atx7, Htt and Atx3) as well as ataxin-2 (Atx2) [48] as model molecules and found that the N-terminal fragment of PQE Atx7 or Htt can sequester AR and Atx3 into insoluble aggregates through direct protein interactions among their polyQ tracts."
37171184