IndraLab

Statements

Reactive Oxygen Species inhibits KCNMA1. 5 / 5
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"Whether ROS activates or inhibits BK channel is debatable."
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"Acute inhibition of ROS with apocynin (a NOX inhibitor) or N-acetylcysteine/EUK-134 (antioxidants) increases BK channel activity in uterine arterial VSMCs of pregnant sheep experiencing gestational hypoxia [259,300,326], suggesting that the BK channel in uterine arteries is tonically inhibited by ROS under hypoxia."
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"Hence, imbalance of antioxidant enzymes plays a critical role in ROS generation in HG, impairing hSlo functions through H (2) O (2)-dependent oxidation at cysteine 911."
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"Also, ONOO − and ROS may inhibit vascular BK channel activity, though O 2− has no effect [115,116] ."
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"Hence, abnormal ROS promoted the Akt/FOXO-3a/FBXO-32-dependent regulation of BK channel degradation in diabetes mellitus."
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