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BCL3 activates CYLD. 3 / 3
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"Moreover, Bcl-3-induced RIP1 deubiquitination can be largely rescued by KO of CYLD (Fig. 7E) and the loss of Bcl-3 similarly suppressed the deubiquitination activity of CYLD (Fig. 7F)."
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"These data revealed that Bcl-3 might promote the formation of both Complex I and Complex II through regulating CYLD participation in complex formation.In this study, we showed an NF-κB-independent role of Bcl-3 in the liver, and our work suggests deletion of Bcl-3 greatly ameliorates TNF-induced liver injury, which provides a potential therapeutic target for various liver diseases."
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reach
"In Cyld deficient keratinocytes, Bcl-3 accumulates in the nucleus, activates the NF-kappaB subunits p50 and p52, and induces the transcription of NF-kappaB target genes such as the cyclin D1 gene.To e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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