IndraLab

Statements

UCHL5 increases the amount of TGFB. 6 / 6
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"In contrast, the transient transfection of UCHL5 (but not the control luciferase) shRNA plasmid attenuated high glucose-induced TGF-βR1 protein expression at 48 h ( Fig. 1 C)."
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"UCH37 knockdown inhibits transcription of TGF-beta target genes and slows lateral cell migration (Cutts et al., 2011)."
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"In other words, UCHL5 increases TGF-βR1 protein levels [11] ."
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"UCH37 knockdown decreases transcription of TGFbeta dependent target genes and also slows lateral cell migration XREF_BIBR."
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"However, the role of UCHL5 in DN remains unknown.With this in mind, we studied the roles of UCHL5 in high glucose-induced TGF-βR1 protein expression in mesangial cells."
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"To further identify the underlying mechanism of high glucose-induced TGF-βR1 protein expression in terms of UCHL5-related deubiquitination pathways, the UCHL5 protein expression was also measured."
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