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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP19 activates cell differentiation. 3 / 3

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"Our previous observations that silencing USP19 induced expression of myofibrillar proteins as well as myogenin in muscle cells suggested that USP19 might modulate muscle cell differentiation."

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"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation dependent induction of the UPR during myogenesis."

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"We therefore tested whether USP19 modulates this differentiation dependent CHOP induction and, if so, whether it requires ER localization."

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Statements

USP19 activates cell differentiation. 3 / 3

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