IndraLab

Statements

USP19 activates cell differentiation. 3 / 3
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"Our previous observations that silencing USP19 induced expression of myofibrillar proteins as well as myogenin in muscle cells suggested that USP19 might modulate muscle cell differentiation."
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"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation dependent induction of the UPR during myogenesis."
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"We therefore tested whether USP19 modulates this differentiation dependent CHOP induction and, if so, whether it requires ER localization."
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