IndraLab

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USP12 deubiquitinates HMGB1. 4 / 4
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"Recently, it was reported that USP12, another USP family member, is highly expressed in multiple myeloma cells and binds to HMGB1 to deubiquitinate and stabilize HMGB1, resulting in the promotion of pro-survival autophagy in myeloma (Li et al. 2022)."
36585612
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"Ubiquitin-specific protease-12 (USP12) interacts with deubiquitylated and stabilized HMGB1, promoting autophagy and conferring bortezomib resistance in myeloma cell lines."
38007142
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"USP12 emerges as a critical regulator in this context, interacting with and deubiquitinating the autophagy mediator, high mobility group box-1 (HMGB1)."
38702734
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"56 In multiple myeloma, the deubiquitination enzyme USP12 deubiquitinates HMGB1 and increase its stability, thus promoting autophagy."
37599832