IndraLab

Statements

USP46 binds ILC3. 5 / 5
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"Additionally, ILC3‐USP46 enriched immune‐regulation‐related GO terms, such as ‘immune response‐activating cell surface receptor signalling’, ‘positive regulation of interferon‐gamma production’, ‘lymphocyte differentiation’, indicating its proinflammatory function."
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"In the other branch, ILC3‐CCR7 cells progress through intermediate states, including ILC3‐USP46 and ILC3‐GNLY, towards transcriptional profiles resembling ILC1/NK cells (Figure  xref )."
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"Intriguingly, unlike ILC3‐CCR7, which is enriched in the normal intestine, the other three subsets of ILC3s (ILC3‐USP46, ILC3‐GNLY and ILC3‐HSPA1B) are primarily distributed in CRC."
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"Unsupervised clustering further identified four transcriptionally distinct subgroups, namely ILC3‐CCR7, ILC3‐HSPA1B, ILC3‐USP46 and ILC3‐GNLY (Figures  xref and xref )."
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"ILC3‐USP46 displayed elevated expression of genes involved in cell adhesion and migration (e.g., SELL and CD38 ), and transcriptional regulation of immune responses (e.g., IRF8 )."
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